The main idea is to play Zabu on turn 2 then Mister Negative on turn 3.
if you are able to do that, SNAP
then i like playing lockjaw if possible, and just go with the flow of the rng of the game.
good combos with this:
-iron man, mystique
-wong, mystique, ironheart wolfsbane
-lockjaw with whatever to bring negatives from deck
-magik on turn 5 or earlier (by lockjaw or locations)
When im not able to play mr negative i go with lockjaw to try to bring negative to game.
obviously there will be bad games, then you surrender, but i've been able to go up ranks with this and it's pretty fun to play, it's quite chaotic and unpredictable but the combos are nice and can generate a lot of power.