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  • Card Preview - Toxie Doxie

Card Preview - Toxie Doxie

News
Cards/Decks
Scosco23
Apr 18, 25

We got a little bit of a surprise when the 4th High Voltage opened. We were expecting to see Dum Dum Duggan as the reward card, but Toxie Doxie was there in his place. Dugan was an interesting card in some ways, but Toxie Doxie is a lot more powerful and fits into more decks than Dugan would have. Selfishly, she fits into the style of decks I most like to play! I'll run through why I like her and give you a few decks to try her out in.


Why are we getting Toxie Doxie?

Toxie Doxie
On Reveal: Give 2 characters in your hand +2 Power. You can't play them next turn.

There's been no word on why we're not getting Dum Dum Dugan, who fits into the What If…? theme and was clearly created alongside the others this season.

Screenshot_20250417-154856

Toxie Doxie is one of the cards that was designed for a past season, but wasn't released—in this case, Dark Avengers from January. Just as Norman Osborne used Daken as a dark counterpart for Wolverine, Moonstone as Ms Marvel, and Bullseye as Hawkeye, Toxie Doxie is also known as the Dark Scarlet Witch. Osborne recruited her for his second go at creating the Dark Avengers, and she's a total psychopath.


Toxie Doxie Synergies

Screenshot_20250417-153656

Cards that love being buffed

Mysterio
On Reveal: Add an Illusion to another location. Activate: Swap Power with it.
Brood
On Reveal: Add 2 Broodlings here with the same Power.
Sebastian Shaw
When this is Empowered, gain an additional +2 Power. (if in hand, in deck, or in play)
Daken
On Reveal: Add the Muramasa Shard to your hand.
Lasher
Activate: Afflict an enemy card here with negative Power equal to this card's Power.
Scarlet Spider
Activate: Add an exact clone of this to another location.
Beta Ray Bill
On Reveal: Shuffle Stormbreaker into your deck.
Iron Man
Ongoing: Your total Power is doubled here.
Black Panther
On Reveal: Double this card's Power.
Ultron Power Stone
On Reveal: Double Infinity Ultron’s Power.

Toxie Doxie says you can't play the card she hits on the following turn, but there are plenty of cards that are thirsty for buffs that tend to hit the board on turns 5 or 6. Surfer will happily just play a different 3-Cost out after Toxie, hand buff decks try to have splashy finals turns, and Iron Man is best at the end of the game with how much Ongoing hate is currently running around. There are plenty of times you won't even notice her downside, especially when you manage to play her on turn 2 or 3.

Cards that get work around her restriction

Of course, we can also actively avoid her downside. War Machine voids it and just allows you to play whatever she hits anyway, meaning she's still fine on turn 5. Jeff is happy to pal around with Toxie anytime and having a buffed mover is always extra powerful. Makkari doesn't need to be played and will occasionally be a free 6 power on board. She-Hulk decks take turns off, occasionally naturally negating Toxie’s downside.

Jeff the Baby Land Shark
Moveable once. Nothing can stop you from moving or playing this to any location.
War Machine
Ongoing: Nothing can stop you from playing cards anywhere.
Makkari
End of Turn: Runs from your hand to a random location. (if possible)
The Infinaut
If you played a card last turn, you can't play this.
She-Hulk
Costs 1 less for each unspent Energy last turn.

Additional Friends

Ravonna Renslayer
Ongoing: Your cards with 1 or less Power cost 1 less. (minimum 1)
Bast
On Reveal: Set the Power of all cards in your hand to 3.
Agent Venom
On Reveal: Set the Power of all cards in your deck to 3.

Ravonna making Toxie cheaper also makes her easier to weave into your curve. She can act as redundancy in Agent Venom decks and still works together with Bast or Agent Venom if she's played after them.


Anti-Synergy

Cards that want to be played with specific timing

Iron Patriot
On Reveal: Add a random {card.TokenEnergyCost_1}-Cost or more card to your hand. If you’re winning here after next turn, give it -{card.ReducedCost} Cost.
Wiccan
On Reveal: If you've spent all your Energy on previous turns, +2 Max Energy.
Kitty Pryde
When this returns to your hand, +1 Power. Returns at the start of each turn.
Deadpool
When Destroyed: Return this to your hand with double the Power.

Playing Toxie Doxie in an Iron Patriot or Wiccan deck is risky. It means you might not be able to play the ideal card to activate your Iron Patriot or Wiccan. Other cards like Kitty Pryde and Deadpool really need to be played out as needed. Toxie Doxie’s downside can be worked around, but she certainly doesn't work with everything.


Scosco's Toxie Doxie Decks

Powerbuff Girls

Buff Surfer

Green Mists

Bio Warfare

Agent Doxie

AgaDoxx

Doxie Hand


Final Thoughts

Toxie Doxie is a card with a positive effect and a tricky downside. Her downside can be worked around pretty easily, but it does mean she loses a lot of value on later turns and it restricts the decks she can go into. In the right decks, she will feel great on turn 2, but you're not always going to draw her then.

At the end of the day, she's an effective 2/5 that plays stronger than that when combined with certain strategies, and she can be earned for free by playing High Voltage. In my mind, that makes Toxie Doxie a clear win for the game generally.

Screenshot_20250417-155326


Who is Scosco23?

You can find more from Scott @FourthLocation on YouTube and fourthlocation.com. He is on social media on Twitter @scodenim and Bluesky @scosco.

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