Per Reddit:
I wrote this guide because I love playing Control Sera. I didn't make this deck, but it has brought me to Infinite for around 3 seasons now, including the Silver Surfer season. It's currently ranked as a Tier 3 deck, but it's so much fun to play and it doesn't need any Series 4 or Series 5 cards.
I have all of the Series 3 cards, Bast, Silver Surfer, She-Hulk, Absorbing Man and Galactus so I can pretty much play anything I want, but this Series 3 only Tier 3 deck is what brought me to Infinite.
HOW TO PLAY Goal is to get to Turn 6 with 2nd priority so that your 3 counter cards (Killmonger, Shang-Chi and Enchantress) can do the maximum amount of damage. The main exception is vs Wong, where you want to Enchantress as soon as you see it.
Make sure to play your cards so that you are 2nd in priority.
Turn 1: SKIP (unless you get extra energy) You want to play Nova on Turn 6 with Killmonger. Nova is easy to hose with Armor, Prof X, etc etc. You want Nova to be a surprise on Turn 6.
Turn 2 - Sentinel is the best play here. Angela also works, but Angela on Turn 6 provides a lot of surprise power.
Alternatively, you can Lizard on a lane with a 1-drop, you will kill it with Killmonger later, or any lane you feel they will not fill up.
Play Armor on their Hood or Nova, that's the main purpose of Armor in this deck, other than playing it on Black Panther or Red Skull to prevent Arnim Zola.
Reserve Mysterio for after Bishop (Turn 4 or Turn 6) to take advantage of the +3 Power
Scarlet Witch is used to change locations - Dream Dimension (+1 cost on Turn 5 prevents your Sera from being played) or any lane that limits your ability to play cards. You want 12 card slots to play cards on.
Turn 3 - Bishop, if you haven't drawn Bishop, same lines of play as Turn 2. I usually end the game with 2 or 3 Sentinels, sometimes 4 Sentinels in play
Turn 4 - Bishop or other 2 drops here. I like Mysterio and Angela as a Turn 6 surprise if you don't need to play your counter cards, otherwise play them here.
Consider Enchantress on Wong, for other decks, Turn 6 Enchantress is much better.
If it looks like they'll play a Leader on Turn 6, play Nova here so that you can have more Powe than them.
Turn 5 - Sera. If you didn't draw Sera, same game plan as Turn 2, 3 and 4. Get your Nova and 2-drops out on this turn if you didn't draw Sera.
Again, try to make sure you are 2nd in priority, unless you need to Enchantress a Wong or Armor for Arnim Zola.
Turn 6 - with Sera you have a bunch of options:
Lots of surprise power on Turn 6 if you don't need to counter anything. Bishop + Mysterio + Nova + Killmonger Three 1-drops + Nova + Killmonger Angela can get to max power even on turn 6
If you need to play your counter cards: Either Enchantress or Shang-chi + Nova + Killmonger wins a lot of 8 cubes. Enchantress + Shang-chi is also great
Without Sera your options are more limited:
Mysterio or 2 drop + Nova + Killmonger is fine. Enchantress or Shang-chi + 2 drop will also be fine.
TURN 6 TRICKS Mysterio is 10 power (4 power, +3 Bishop, + 3 spread on Nova).
Enchantress on Armor protected fatties + Shang-chi is delicious. Even your own Armor. Other players will play their fatties on your Armor.
Scarlet Witch on Wakanda + Killmonger / Shang-chi
Scarlet Witch on Death's Domain, Danger Room, and Luke's Bar. You also want to Scarlet Witch Kamar-Taj since none of your on reveal cards benefit from it.
Armor on Death's Domain and Danger Room.
Play Lizard on full lanes + Killmonger or Shang-chi.
Enchantress targets on Turn 6 - Iron Man, Devil Dino, Armor (especially if they will play Destroyer), Patriot, Blue Marvel, Mystique, Onslaught, Cerebro
If you are anticipating Spectrum, Enchantress turns ongoing cards into no ability cards and they won't get the buff (but you need priority here, if Spectrum reveals first, they will get the buff).
On Washington D.C., if you play Armor, Lizard or Sera (ongoing cards) then play Enchantress on. them on turn 6, you will turn them into no ability cards and they get the +3 buff. Cool little trick.
Enchantress on Lizard in a full lane is also a decent play.
This deck hates Cosmo, so play around it.
This deck consistently beats: Patriot Ultron (Enchantress + Killmonger)
Devil Dino decks (Enchantress + Shang-chi, and Killmonger for Agent 13 and Quinjet)
DeathWave / She-Hulk Baero (Shang Chi, and since you can fill up most of your slots, Aero can be played around)
and decks that play Leader. Turn 6 Leader is countered by (#1) Angela, your lanes get extra power, they don't. (#2) Mysterio since their copy has 0 power, yours is 4 power, (#3) Nova + Killmonger (better if Nova is played before Turn 6) or you can try to make sure to play Nova in lanes that are full, so they don't get to copy, and then Killmonger will only buff your cards and (#4) Shang-chi because it doesn't hit any cards on your side.
CARD NOTES Nova - better on Turn 6, play earlier if you don't draw Sera.
Angela - reserve for Turn 6 for surprise power, but is fine earlier. Helps vs Leader.
Armor - counter Hood, Nova, Bucky Barnes, Arnim Zola. Can be a flex slot.
Scarlet Witch - Dream Dimension, Kamar-Taj, Death's Domain, Space Throne, etc. Any location that prevents you from playing cards.
Sentinel - play as many as you can.
Mysterio - play after Bishop, Turn 6 surprise with Nova.
Lizard - play on lanes where they have a 1-drop or a 9-power card, then use Killmonger or Shang-chi to open it up.
Bishop - play as early as you can
Killmonger - combo with Nova, help Lizard
Shang-chi - play on Turn 6 for 8 cubes, help Lizard
Enchantress - play on Turn 6 for 8 cubes, turn off Wong as early as you can
Sera - play on Turn 5. If not, retreat unless you have a good read.
Hope you had fun reading this. I enjoyed writing it, but not as much as I enjoy playing Control Sera.