Every tagged card except for maybe Goblin, Sera, and Magik are essential to this deck.
In mostly all other ecks you try and win the game by stacking your lane with cards and trying to push as much power as you can into two lanes. With this deck you let your opponent fill there lane and you take all their power away late game by putting them in a negative state.
You want to save 1 safe lane for as your combo lane which will be(in this order: Wong, Mystique, Hazmat, then Odin). The other Lanes you use to try and help build up your combo, with cards like Pylocke, Magik, and Sera. Thought it is IMPORTANT that you have Luke Cage on the board so only your opponent take the negative effect.
The "non-essential" cards all play a role aswell
Gambit is a great alternative win condition to place in your combo lane in place of hazmat becaus he works well with Wong+Mystique+Odin.
Scorpion just adds a small amount of extra negative effect to your opponent, plus he can disrupt certain decks like Cerebro decks
Typhoid Mary is a 4 cost 10 power card and her effect is canceled out by Luke Cage
Absorbing Man can copy Hazmat or Odin(if you magik)
Black Widow gives your opponent a 0 cost cards and can prevent them from drawing the combo cards they need
Colossus doesn't take any negative effect at all
Viper is only good to use if you use The Hood leaving your opponent with a -2 and taking up a slot that they could've used and leaving you with a 1 cost 6 power card.(thos these too are probably the least useful because it's inconsistent and Goblin does the same)
This deck isn't very meta and you need to draw multiple specific cards to pull off the combo so it can be very inconsistent but it can work if you don't get all the cards for the combo, but when you do pull it off watching your opponents big numbers go down is very satisfying.