Curious if combining C3r3bro with the Zabu Double Webs strategy could be an effective two-pronged attack. I don't have Valkyrie so somebody else would have to test this. Not 100% sold on the other 3-power cards though, especially Rhino (how badly do I need two location disruption effects?) & Shang-Chi (seems somewhat redundant with Valkyrie). Wish there were more 4-cost 3-power cards to choose from, but I doubt a Ghost Rider package is worth it.
Core:
Zabu, Spider-Man, Absorbing Man - the double web package
Cerebro, Mystique - the C3r3bro package
Stats:
Hawkeye: The best 1-cost 3-power option without a discard subtheme (which we don't have room for)
Sentinel: The best way to get a lot of 3-power cards on board (sadly, we don't have a Mister Sinister or Brood equivalent)
Valkyrie: Easy to win a location with either Cerebro active or if it was locked down by a web
Tech Cards:
Scarlet Witch, Rhino: A ton of locations disrupt Cerebro, and we need one or two ways to deal with them
Cosmo: Protects Cerebro or Mystique (after played), and answers many opposing strategies
Shang-Chi: Our only other card that benefits from Zabu, and a useful tech card in it's own right
Other Options:
Killmonger, Armor: Also effective tech cards w/ 3 power, but seem less relevant than Cosmo. May be more effective than Shang-Chi or Rhino
Magik: An alternative to Rhino for a second way to disrupt bad locations, but an extra turn works at odds with the Spider-Man plan.
Blue Marvel: Still the best option for a second Mystique target despite not benefiting from Cerebro if you just need more stats