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Main strategy: win one location by adding negative power cards to the opponent side (hood+viper, green goblin+debri) and try to make 4 cards for opponent with titania, this will prevent him from playing card here and you can pull titania back later in the game. Second winning location comes with Dock Ock + Shang-Chi. Even without pulling these combos you can manage to win locations due to sunspot, mojo, aero. You can also add cards like polaris or hobgoblin.
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