With Shuri and Thanos decks being rampant, I choose to play a deck limiting they're options to play, by quickly locking lanes.
Ideal scenario would be Daredevil T2, Storm T3 into Juggernaut T4 locking one lane, and then thanks to Daredevil, lock the second lane with Chuck aka Prof X or Spider-Man. Doctor Doom will help give additional power behind Spider-Man or Storm on T6.
If a Shuri player were to slid a Red Skull past you, you have the Shang-Chi to deal with it. Armor and Cosmo are there to deal with any Nimrod shenaningans going around right now.
Be aware of Galactus and try to lock the lane where they would most probably play them. Often a Wave turn 3 could mean a Galactus is being played early.
Iceman/Scorpion are there to slow down the opponent's plan until you can begin with yours and She-Hulk in case you need big power on one-lane instead of spreading it with Doctor Doom, while still giving you the flexibility to play her earlier if you floated some mana.
You can eventually switch a Scorpion with Sunspot and She-Hulk with your big-hitter of choice or Aero (which I don't own, but the deck is working just fine as it is for me).
Also the Armor/Cosmo package can be switched with any tech you need to deal with the decks you have problem encountering, for example, using Killmonger to deal with Thanos and his stones.