Gwen the Protector

Game plan as follows:

Set up priority in the early game

Play Sauron

Play Shuri

Play Red Skull

At this point, your opponent will either have Shang-Chi to beat Red Skull, or give the lane up and focus the other two.

Play Ghost Spider to move Red Skull out of the lane and replace it with unshangable power (Lizard/Polaris any card larger than Shang-Chi will do). Alternative turn six is Taskmaster as usual.