This deck can be a good counter to a lot of decks ! One of our best matchups is Galactus : we have Daredevil, Goose, Cosmo, Polaris, Juggernaut, Prof. X... BLOCK HIM ASAP !
Of course it can also screw move decks, which are popular at the moment. Just be careful not to play cards like Polaris or Juggernaut.
I think you can swap Iceman, Goose and Jeff for anything you prefer, such as Lizard, Cloak, Sentinel, Star-Lord/Rocket Raccoon, Domino, Scorpion, Master Mold... (post-OTA edit : Medusa seems awesome too ! )
You can go full control with Spider-Man as well (maybe not anymore since he is a 5-cost), or run a heavier Daredevil package (DD + Prof. X + Gamora for more options and power)
For me, the missing piece of this deck is Stryfe. If he is released one day and if his power and effect are not changed, we could take advantage of him and protect him with Professor X or Juggernaut.
Post-patch edit : Dazzler can easily be a 3-6 in this deck, and a 3-8 with Surfer's boost !