TOTRY lockdown

medusa, kitty pride, or the hood in the middle with beast to bounce them, creates insane value (medusa becomes 1/8, kitty is just a +2 powerhouse, the hood creates 2 demons)
Sentry + Viper or The Hood + viper is quite insane. As you wont always have an option to viper the -10 power, -3 power from the hood is like a green goblin, but better. You have to be careful with people running destroy because they could potentially destroy the negative power.