Hamper opponent’s early plays with Iceman, Kong, and especially Black Widow. If they are playing lots of one cost cards, hold Killmonger until turn 5 or 6. If they are buffing (Kazar, Wong, Blue Marvel, Mystique, Silver Surfer, Patriot), try to depower with Enchantress T6 or T5. If it looks more like an on-reveal attack (e.g., opponent plays Wong and you suspect White Tiger and Odin), block with Cosmo. If opponent is putting down power, break up their distribution with Green Goblin and Juggernaut. If it looks like they will play their buffs / specials on T5/T6, use Leech. Try for a win with She-Hulk T5 in her own lane / Arnim Zola T6 or hulks T5 & T6.
This deck does poorly vs Dracula as that card often comes out before Leech can depower it, and neither Enchantress nor Cosmo can touch Dracula’s ability.