Shuri'ing a Red-Skull typically wins that lane. So forcing the opponents to put more power there is a way to disrupt the opponents plans.
Ideal Play line
T3 - Jean on a location where Jeff or another card (Except Nebula) is already there. Bonus, play Jean into an armored location. This way, you can fill the location faster if needed.
T4 - Shuri. This deck's linchpin is Shuri.
T5 - Redskull or Vision. If you are unlucky and haven't drawn both. Captain Marvel. By now, the location should be filled up. Ideally. Or move Jeff to fill up.
T6 - Taskmaster, Titania in other locations. Move Vision out if he is doubled. If forced to play on Jean grey's location, Captain Marvel there, so she can fly away. Or you can even go for a Zero Redskull play on T6 if you drew Red Skull late.
Control - If the opponent is playing a Destroy deck or PF deck, Jean on Armored lane essentially wins the game.
Against Lockdown decks, Vision and CM should be a good match up.