This should be a self-explanatory deck; there isn't any weird or nuanced stuff. It was originally built as a list of cards that work well with Baron Mordo, which is why he is here (and marked as essential). The combination of the Disruption archetype with a Pixie deck works well for many reasons. Many of Disruption's staples are 1, 5, and 6-Cost cards, although some are 3-Cost. The negative effects that Pixie may provide are felt less because of how much of Disruption cards' values are based on your opponent's cards. The positive effects that Pixie may provide are felt even more due to the power of the surprise plays they can offer (seen mainly in the suggested cards for this deck) and the tempo they can give you. The two deck styles also share some common cards, like Mobius M. Mobius.
Nebula, Storm, Goose, Crossbones, and Sandman benefit from your opponent being restricted from playing cards early. Red Hulk, Negasonic Teenage Warhead, Ronan the Accuser, and Alioth benefit from your opponent being able to play very few cards overall. Silver Samurai, Black Widow, and Black Bolt further reduce your opponent's options. Additionally, Silver Samurai will almost always hit a Nebula or Pixie in your hand, which are far less useful at that point in the game, and Black Bolt will never conflict with Baron Mordo. Spider-Ham, Selene, Silver Sable, and Cassandra Nova make your opponent's existing options much worse and will almost never conflict with Baron Mordo. Cannonball, Nocturne, Copycat, and Spider-Ham are generally good cards with variable value, making them work well with Pixie. They also add to the disruptive potential of the deck. Mobius M. Mobius, Black Swan, and Nico Minoru are in the deck to support Pixie, and Mobius in particular can add even more disruption in some match-ups.